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Vitamin D levels and left ventricular function in beta-thalassemia major with iron overload.
- Source :
-
European Journal of Pediatrics . Apr2023, Vol. 182 Issue 4, p1749-1754. 6p. 4 Charts, 1 Graph. - Publication Year :
- 2023
-
Abstract
- Heart disease is the primary cause of death in patients with beta-thalassemia major. The study aimed to determine the association between vitamin D and left ventricular function in patients with beta-thalassemia major with iron overload. A cross-sectional hospital-based study was conducted, where the vitamin D and ferritin levels of children living with beta-thalassemia major were measured, and left ventricular function was assessed utilizing ejection fraction (EF) and fractional shortening (FS) using 2D echocardiography. The mean serum ferritin was 4622 ± 2289 ng/ml, and the mean serum vitamin D levels were 22 ± 7.7 ng/ml. The mean values of EF were 62.30 ± 6.9%, and FS was 31.21 ± 4.8%. Statistically significant negative correlation (r = −0.447, p < 0.001) was found between vitamin D and serum ferritin values, and a significant positive association was found between vitamin D levels concerning EF and FS with a p-value of 0.034 and 0.014, respectively. Conclusion: It was observed that increasing ferritin was associated with lower vitamin D levels which in turn influenced fractional shortening /cardiac function in these patients. What is Known: • Patients with Beta Thalassemia major on long term transfusion are prone to develop heart disease / cardiac failure due to chronic iron overload. What is New: • Patients with beta thalassemia major on long term term transfusions with iron overload who are vitamin D deficient are more prone to the cardiac complications which inturn can be prevented by vitamin D supplementation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *VITAMIN D
*IRON overload
*BETA-Thalassemia
*DIETARY supplements
*HEART failure
Subjects
Details
- Language :
- English
- ISSN :
- 03406199
- Volume :
- 182
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- European Journal of Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 163613785
- Full Text :
- https://doi.org/10.1007/s00431-023-04830-7