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Secondary metabolites from the Cordyceps-colonizing fungus Aspergillus versicolor ZJUTE2.
- Source :
-
Fitoterapia . Jun2023, Vol. 167, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- Two new polyketides versicolorones A-B (1 – 2), one new diketopiperazine derivative aspergiamide B methyl ester (3), along with twenty known compounds 4 – 23 , were obtained from the EtOAc extract of the Cordyceps -colonizing fungus Aspergillus versicolor ZJUTE2. The structures of 1 – 3 were established by detailed interpretation of the spectroscopic data and their absolute configurations were established by comparative analyses of the calculated and experimental ECD spectra. In the in-vitro bioassay, compounds 8 and 21 exhibited significant inhibitory activity against the Escherichia coli β -glucuronidase (EcGUS) with IC 50 values of 54.73 ± 2.69 and 56.59 ± 1.77 μM, respectively. [Display omitted] [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 167
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 163697508
- Full Text :
- https://doi.org/10.1016/j.fitote.2023.105501