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Asymmetric Total Synthesis of Naphthospironone A.

Authors :
Liu, Jia‐Xuan
Zhang, Shi‐Peng
Sun, Feng‐Sen
Li, Hui
Gong, Ya‐Ling
Lu, Shi‐Chao
Xu, Shu
Source :
Angewandte Chemie. 5/22/2023, Vol. 135 Issue 22, p1-4. 4p.
Publication Year :
2023

Abstract

Naphthospironone A, a polyhydroxy cagelike bioactive natural product, was synthesised for the first time in this study. The spiro[bicyclo[3.2.1]octane‐pyran] core was constructed by an acid‐promoted epoxide‐opening lactonisation and a base‐induced intramolecular aldol‐type cyclisation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00448249
Volume :
135
Issue :
22
Database :
Academic Search Index
Journal :
Angewandte Chemie
Publication Type :
Academic Journal
Accession number :
163705278
Full Text :
https://doi.org/10.1002/ange.202303229