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Stem Cell Oriented Exosomes Regulate Cell Proliferation in Hepatoma Carcinoma.
- Source :
-
Biotechnology & Bioprocess Engineering . Apr2023, Vol. 28 Issue 2, p263-273. 11p. - Publication Year :
- 2023
-
Abstract
- Reprogrammed hepatic stem cells can generate a variety of extracellular vesicular particles including exosomes with similar therapeutic potential. However, their functional application in cancer therapy is restricted due to a poor understanding of their physical properties, anti-proliferative effects, and the underlying mechanism. Here, we explore reprogrammed stem cells that can release vesicular particles with physical properties of exosomes that can exert anti-proliferative effects by regulating cell proliferation-related genes. We obtain vesicular particles with properties of exosomes expressing CD81 and CD63 with the size distribution peak observed at 155 nm. We analyze that as compared to non-treated conditions, vesicular particles have reduced cell proliferation of Hep G2 by 93.6% after 72 h. Furthermore, we also identify that B-cell lymphoma 2 has been reduced by 89.64% and activation of caspase-3 has occurred in treated conditions via the mitochondrial pathway. Therefore, our results may highlight the potential of exosomes from hepatic stem cells to play a vital role in treating liver pathologies. [ABSTRACT FROM AUTHOR]
- Subjects :
- *STEM cells
*CELL proliferation
*EXOSOMES
*LIVER cells
*HEPATOCELLULAR carcinoma
Subjects
Details
- Language :
- English
- ISSN :
- 12268372
- Volume :
- 28
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Biotechnology & Bioprocess Engineering
- Publication Type :
- Academic Journal
- Accession number :
- 163727163
- Full Text :
- https://doi.org/10.1007/s12257-022-0238-y