Highly Regioselective Synthesis of N‐β‐trifluoromethyl 2‐pyridones via anti‐Markovnikov Hydroamination of α‐(trifluoromethyl)styrenes with 2‐pyridones.

A novel and facile method for the synthesis of N‐β‐CF3‐substituted 2‐pyridones via hydroamination of α‐(trifluoromethyl)styrenes with 2‐pyridones was described. The reaction proceeded smoothly at room temperature, affording a variety of N‐(β‐trifluoromethyl‐β‐arylethyl)pyridin‐2(1H)‐ones in moderate to good yields with excellent N‐regioselectivity. [ABSTRACT FROM AUTHOR]