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Neutral BODIPY derivatives as photosensitizers.
- Source :
-
Journal of Photochemistry & Photobiology A: Chemistry . Aug2023, Vol. 442, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- [Display omitted] • Syntheses of a series of dibromo- and diiodo-BODIPY derivatives. • Compared photostability and photosensitization efficiency of BODIPY derivatives. • Antibacterial activity against B. subtilis by BODIPY containing tertiary amine. A series of 2,6-dibromo-, 2,6-diiodo-4,4-difluoro-4-bora-3a,4a-diaza- s -indacene, together with the 4,4-dicyano analogs were synthesized. The photostability of these BODIPY derivatives and their efficiencies in generating singlet oxygen species were determined. Among these, 2,6-dibromo-4,4-dicyano-4-bora-3a,4a-diaza- s -indacene (BODIPY 6) was found to be similarly photostable as Rose Bengal, while 2,6-diiodo-8-iodomethyl-1,3,5,7-tetramethyl-4,4-difluoro-4-bora-3a,4a-diaza- s -indacene (BODIPY 10) and 1,3,5,7,8-pentamethyl-2,6-diiodo-4,4-dicyano-4-bora-3a,4a-diaza- s -indacene (BODIPY 5) were found to be the least stable. For the ability to generate singlet oxygen species, 2,6-dibromo- (BODIPY 3) and 2,6-diiodo-4,4-difluoro-4-bora-3a,4a-diaza- s -indacene (BODIPY 2) were found to be more efficient than Rose Bengal, while BODIPY 10 and 1,3,5,7,8-pentamethyl-2,6-diiodo-4,4-dicyano-4-bora-3a,4a-diaza- s -indacene (BODIPY 5) were quite poor photosensitizers. When Bacillus subtilus cultures were supplemented with the photosensitizers and exposed to light, it was found that the presence of a positive charge in the photosensitizers was essential in order for them to be effective bacterialcidal agents. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10106030
- Volume :
- 442
- Database :
- Academic Search Index
- Journal :
- Journal of Photochemistry & Photobiology A: Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 163820339
- Full Text :
- https://doi.org/10.1016/j.jphotochem.2023.114770