ASSOCIATION OF SERUM VITAMIN D AND LDH WITH THYROID HORMONE PROFILE IN HYPERTHYROIDISM.

Introduction: Thyroid disorders are considered the most common endocrine disorders affecting 5-10% of individuals. Vitamin D is an important bio-molecule that plays a role in the signaling pathways related to immune modulation and oxidative stress. Vitamin D receptor (VDR) gene polymorphisms were found to be associated with the risk for Graves' disease. As thyroid hormones are essential for normal organ growth, development function the basal metabolic rate of all cells, its alteration can affect the entire metabolism and can alter the activity of serum enzymes like LDH. There is negotiation regarding the increased/decreased levels of LDH in thyroid disorders with some studies stating that LDH can be used as a parameter for screening the thyroid disorder. But some contraindicated results prevail in this area of research. To clear some air an attempt was made on one study group to analyse the levels of LDH and Vitamin D in hyperthyroidism disorder and to find out correlation (if any) that exists between LDH and thyroid hormone. Aim and Objectives: To estimate the levels of serum LDH and vitamin D in hyperthyroid patients and to correlate with TSH, T3 and T4 and also to see the mutual correlation. Materials and methods: The study population was serum specimens from 100 patients with hyperthyroidism with ages ranging from 20-40 years. The samples were collected from the Thyroid laboratory, Department of Biochemistry, PGIMS, Rohtak. The levels of LDH and Vitamin D were determined on the autoanalyzer and radioimmunoassay respectively. Results and conclusion: The mean values for LDH and Vitamin D in hyperthyroidism patient were found to be 280.17±52.43 and 13.83±4.71 respectively. Regression analysis of different parameters was also done. Our findings support that hyperthyroid patients have subtle disturbances of LDH and Vitamin D level. [ABSTRACT FROM AUTHOR]