七氟醚联合瑞芬太尼维持麻醉对介入治疗颅内动脉瘤患者神经功能、 认知功能、炎性因子的影响.

Objective: To investigate the effects of sevoflurane combined with remifentanil on neurologic function, cognitive function and inflammatory factors in patients with intracranial aneurysms undergoing interventional therapy. Methods: 80 patients with intracranial aneurysms who underwent interventional surgery in our hospital from January 2020 to June 2022 were selected and divided into group A(sevoflurane combined with remifentanil) and group B(propofol combined with remifentanil) according to different anesthesia methods, with 40 patients in each group. Neurological function, cognitive function and inflammatory factor level were compared between the two groups. Results: The heart rate(HR) and mean arterial pressure(MAP) of group A were better than those of group B from T1 to T3(P＜0.05). The national institutes of health stroke scale(NIHSS) score of group A was significantly lower than that of group B at 24 h and 7 d after operation(P＜0.05), and the mini-mental state examination(MMSE) score was higher than that of group B(P＜0.05).Serum tumor necrosis factor-α(TNF-α), C-reactive protein(CRP), and interleukin-6(IL-6) levels at 24 h and 3 d after operation in group A were lower than those in group B(P＜0.05). The recovery time of spontaneous respiration, recovery time, extubation time and the incidence of agitation after extubation in group A were lower than those in group B(P＜0.05). The adverse effects were not different(P＞0.05).Conclusion: The application of sevoflurane combined with remifentanil maintenance anesthesia in interventional IA patients can smooth hemodynamics, improve postoperative neurological function and cognitive function, reduce inflammatory response, and improve the quality of anesthesia awakening. [ABSTRACT FROM AUTHOR]