急性心肌梗死患者血清Clusterin、GMP140 与冠状动脉病变 和心血管不良事件的关系研究.

Objective: To investigate the relationship between serum clusterin (CLU) and granule membrane protein 140 (GMP140) and coronary artery lesions and major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI). Methods: 129 patients with AMI who were admitted to our hospital from January 2020 to December 2021 were selected as the AMI group. According to the number of coronary artery lesions, they were divided into single vessel lesion group (n=34), double vessel lesion group (n=50), and multi vessel lesion group (n=45). The patients were followed up for 6 months and divided into MACE group and non-MACE group according to whether MACE occurred. Another 55 healthy volunteers in the same period were selected as the control group. The clinical data of patients with AMI were collected, and the serum CLU and GMP140 levels were detected by enzyme-linked immunosorbent assay. Multivariate Logistic regression was used to analyze the influencing factors of MACE in patients with AMI, and the predictive value of serum CLU and GMP140 levels on MACE in patients with AMI was analyzed by the receiver operating characteristic (ROC) curve. Results: Serum CLU and GMP140 levels in the AMI group were higher than those in the control group (P<0.05). The serum CLU and GMP140 levels in the single vessel disease group, double vessel disease group and multi vessel disease group increased in turn (P<0.05). 6 months after follow-up, the incidence of MACE in 129 patients with AMI was 25.58% (33/129). Multivariate Logistic regression analysis showed that elevated left ventricular ejection fraction was independent protective factor, increased age, ST segment elevation myocardial infarction, KILLIP grade≥III, elevated low density lipoprotein cholesterol (LDL-C), elevated CLU and elevated GMP140 were independent risk factors for MACE in patients with AMI (P<0.05). ROC curve analysis showed that the area under curve of MACE predicted by serum CLU and GMP140 levels in patients with AMI was greater than that predicted by CLU and GMP140 alone (P<0.05). Conclusion: Elevated serum CLU and GMP 140 levels in patients with AMI are associated with coronary artery lesions and MACE, and which may be an auxiliary predictor of MACE in patients with AMI. [ABSTRACT FROM AUTHOR]