慢性鼻窦炎患者嗅觉障碍的危险因素探讨及其对患者心理健康 和生存质量的影响.

Objective: To investigate the risk factors of olfactory dysfunction in patients with chronic sinusitis and its effect on mental health and quality of life of patients. Methods: 120 patients with chronic sinusitis who were admitted to Beijing Tongren Hospital Affiliated to Capital Medical University from September 2017 to September 2020 were selected for olfactory function test. The incidence of olfactory dysfunction was analyzed, and patients were divided into olfactory dysfunction group (n=64) and olfactory normal group (n=56) according to the olfactory function test. The basic data, clinical data, mental health status and quality of life of patients in the two groups were compared and analyzed. The influencing factors of olfactory dysfunction in patients with chronic sinusitis were analyzed by univariate analysis, and risk factors of olfactory dysfunction in patients with chronic sinusitis were analyzed by multivariate Logistic regression. Results: According to the olfactory function test results, 64 of the 120 patients showed olfactory dysfunction, and the prevalence rate of olfactory dysfunction was 53.33%, included 36 cases (56.25%) of male patients, and 28 cases (43.75%) of female patients. 46 cases (38.33%) had hypoolfactory, and 18 cases (15.00%) had anosmia. Univariate analysis showed that nasal endoscopic surgery history, concomitant nasal polyp, asthma history, proportion of eosinophils and nasal endoscopic Lund-Kennedy score were the influential factors for the occurrence of anosmia in chronic sinusitis (all P<0.05). Multivariate Logistic regression analysis showed that nasal endoscopic surgery history, concomitant nasal polyp, asthma history, proportion of eosinophil ＞5%, and nasal endoscopic Lund-Kennedy score ≥2 scores were independent risk factors for olfaction of chronic sinusitis. The scores of anxiety self-rating Scale (SAS) and depression self-rating Scale (SDS) in the olfactory normal group were lower than those in the olfactory dysfunction group (P<0.05). The score of quality of life (SF-36) for each dimension in the olfactory normal group was higher than that in the olfactory dysfunction group (P<0.05). Conclusion: The incidence of anosmia is higher in patients with chronic sinusitis, and the risk factors for anosmia are nasal endoscopic surgery history, concomitant nasal polyp, asthma history, proportion of eosinophilia ＞5% and Lund-Kennedy score ≥2 scores. At the same time, olfactory disorder can also cause depression and anxiety and other adverse emotions, reducing the quality of life of patients. [ABSTRACT FROM AUTHOR]