Back to Search
Start Over
Benzodipyrazoles: a new class of potent CDK2 inhibitors
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Mar2005, Vol. 15 Issue 5, p1315-1319. 5p. - Publication Year :
- 2005
-
Abstract
- Abstract: The synthesis and the preliminary expansion of this new class of CDK2 inhibitors are presented. The synthesis was accomplished using a solution-phase protocol amenable to rapid parallel expansion and suitable to be scaled-up in view of possible lead development. Following a medicinal chemistry program aimed at improving cell permeability and selectivity, a series of compounds with nanomolar activity in the biochemical assay and able to efficiently inhibit tumor cell proliferation has been obtained. [Copyright &y& Elsevier]
- Subjects :
- *TUMORS
*CELL proliferation
*PHARMACEUTICAL chemistry
*PERMEABILITY
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 15
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 16392873
- Full Text :
- https://doi.org/10.1016/j.bmcl.2005.01.023