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(E)-Phenyl- and -heteroaryl-substituted O-benzoyl-(or acyl)oximes as lipoprotein-associated phospholipase A2 inhibitors
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Mar2005, Vol. 15 Issue 5, p1525-1527. 3p. - Publication Year :
- 2005
-
Abstract
- Abstract: A series of (E)-phenyl- and -heteroaryl-substituted O-benzoyl- (or acyl)oximes 3a–n were synthesized for evaluating their human lipoprotein-associated phospholiphase A2 (Lp-PLA2) inhibitory activities. The less lipophilic derivatives 3a–c showed the most potent in vitro inhibitory activity on human Lp-PLA2. [Copyright &y& Elsevier]
- Subjects :
- *LIPOPROTEINS
*PHENYL compounds
*BENZOYLPHENYL ureas
*LIPIDS
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 15
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 16392918
- Full Text :
- https://doi.org/10.1016/j.bmcl.2004.11.063