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Caveolin-1 and Atherosclerosis: Regulation of LDLs Fate in Endothelial Cells.
- Source :
-
International Journal of Molecular Sciences . May2023, Vol. 24 Issue 10, p8869. 14p. - Publication Year :
- 2023
-
Abstract
- Caveolae are 50–100 nm cell surface plasma membrane invaginations observed in terminally differentiated cells. They are characterized by the presence of the protein marker caveolin-1. Caveolae and caveolin-1 are involved in regulating several signal transduction pathways and processes. It is well recognized that they have a central role as regulators of atherosclerosis. Caveolin-1 and caveolae are present in most of the cells involved in the development of atherosclerosis, including endothelial cells, macrophages, and smooth muscle cells, with evidence of either pro- or anti-atherogenic functions depending on the cell type examined. Here, we focused on the role of caveolin-1 in the regulation of the LDLs' fate in endothelial cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CAVEOLINS
*ENDOTHELIAL cells
*CAVEOLAE
*MUSCLE cells
*ATHEROSCLEROSIS
Subjects
Details
- Language :
- English
- ISSN :
- 16616596
- Volume :
- 24
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- International Journal of Molecular Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 163966533
- Full Text :
- https://doi.org/10.3390/ijms24108869