Resolving the etiology and treatments of allergic diseases.

Yang and colleagues expounded two possible pathways contributing to pollen's effect on COVID-19 infection using a multiple-adjusted generalized additive (GAM) model.[12] Besides further recognizing the features of allergy,[13] knowing the allergen-encoding genes and their isoforms at the chromosomal level may also help us to detect novel allergens.[14] Zhao and colleagues have identified three well-recognized mango fruit allergen molecules by using combined omics tools and immunological methods. It has now been over 3 years since the coronavirus disease 2019 (COVID-19) was declared a global pandemic, and its end now appears to be in sight. The latest progress and contributions of these scholars in understanding the "epithelial barrier theory" as the gateway to allergic diseases, allergen recognition, and promising treatments are highlighted in this special "China Issue" of I Allergy i (Figure 1). [Extracted from the article]