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Photoenzymatic Hydrosulfonylation for the Stereoselective Synthesis of Chiral Sulfones.
- Source :
-
Angewandte Chemie International Edition . 6/5/2023, Vol. 62 Issue 23, p1-5. 5p. - Publication Year :
- 2023
-
Abstract
- Chiral sulfones are recurrent motifs in pharmaceuticals and bioactive molecules. Although chemical methods have been developed to afford α‐ or β‐ chiral sulfones, these protocols rely heavily on the pre‐synthesis of structurally complicated starting materials and chiral metal complexes. Herein, we described a photoenzymatic approach for the radical‐mediated stereoselective hydrosulfonylation. Engineered variants of ene reductases provide efficient biocatalysts for this transformation, enabling to achieve a series of β‐chiral sulfonyl compounds with high yields (up to 92 %) and excellent e.r. values (up to 99 : 1). [ABSTRACT FROM AUTHOR]
- Subjects :
- *SULFONYL compounds
*SULFONES
*REDUCTASES
*METAL complexes
*ENZYMES
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 62
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 164094056
- Full Text :
- https://doi.org/10.1002/anie.202218140