Design and development of second-generation fabric phase sorptive extraction membranes: Proof-of-concept for the extraction of organophosphorus pesticides from apple juice prior to GC–MS analysis.

[Display omitted] • Design of second generation TiO 2 based FPSE membranes. • Analysis of clarified and unclarified apple juice samples. • Development of an FPSE-GC–MS method for OPPs determination. • Higher extraction efficiency for OPPs compared to their silica analogues. In this work, different sol–gel sorbent-coated second-generation fabric phase sorptive extraction (FPSE) membranes were synthesized using titania-based sol–gel precursors. The proposed membranes were tested for their efficiency to extract eleven selected organophosphorus pesticides (OPPs) from apple juice samples. Among the examined materials, sol–gel C 18 coated titania-based FPSE membranes showed the highest extraction efficiency. These membranes were used for the optimization and validation of an FPSE method prior to analysis by gas chromatography-mass spectrometry. The detection limits for OPPs ranged between 0.03 and 0.08 ng mL−1. Moreover, the relative standard deviation was < 8.2% and 8.4% for intra-day and inter-day studies, respectively. The relative recoveries were 91–110% (intra-day study) and 90–106% (inter-day study) for all the target analytes, demonstrating good overall method accuracy. Moreover, the novel membranes were reusable at least 5 times. The titania-based membranes were compared to the conventional silica-based membranes and their utilization resulted in higher extraction recoveries. [ABSTRACT FROM AUTHOR]