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Purpurin ameliorates D-galactose-induced aging phenotypes in mouse hippocampus by reducing inflammatory responses.
- Source :
-
Neurochemistry International . Jul2023, Vol. 167, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- Purpurin, an anthraquinone, has potent anti-oxidant and anti-inflammatory effects in various types of brain damage. In a previous study, we showed that purpurin exerts neuroprotective effects against oxidative and ischemic damage by reducing pro-inflammatory cytokines. In the present study, we investigated the effects of purpurin against D-galactose-induced aging phenotypes in mice. Exposure to 100 mM D-galactose significantly decreased cell viability in HT22 cells, and purpurin treatment significantly ameliorated the reduction of cell viability, formation of reactive oxygen species, and lipid peroxidation in a concentration-dependent manner. Treatment with 6 mg/kg purpurin significantly improved D-galactose-induced memory impairment in the Morris water maze test in C57BL/6 mice and alleviated the reduction of proliferating cells and neuroblasts in the subgranular zone of the dentate gyrus. In addition, purpurin treatment significantly mitigated D-galactose-induced changes of microglial morphology in the mouse hippocampus and the release of pro-inflammatory cytokines such as interleukin-1β, interleukin-6, and tumor necrosis factor-α. In addition, purpurin treatment significantly ameliorated D-galactose-induced phosphorylation of c-Jun N-terminal kinase and cleavage of caspase-3 in HT22 cells. These results suggest that purpurin can delay aging by reducing the inflammatory cascade and phosphorylation of the c-Jun N-terminal in the hippocampus. • Purpurin ameliorates D-galactose-induced cell death, ROS formation, and lipid peroxidation in HT22 cells. • Purpurin alleviates impairments in memory formation and hippocampal neurogenesis induced by D-galactose treatment. • Purpurin decreases pro-inflammatory cytokine releases and JNK phosphorylation in D-galactose-treated mice. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01970186
- Volume :
- 167
- Database :
- Academic Search Index
- Journal :
- Neurochemistry International
- Publication Type :
- Academic Journal
- Accession number :
- 164131930
- Full Text :
- https://doi.org/10.1016/j.neuint.2023.105552