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Insights into the solubility of γD‐crystallin from multiscale atomistic simulations.
- Source :
-
Journal of Computational Chemistry . 7/15/2023, Vol. 44 Issue 19, p1658-1666. 9p. - Publication Year :
- 2023
-
Abstract
- The molecular basis underlying the rich phase behavior of globular proteins remains poorly understood. We use atomistic multiscale molecular simulations to model the solution‐state conformational dynamics and interprotein interactions of γD‐crystallin and its P23T‐R36S mutant, which drastically limits the protein solubility, at both infinite dilution and at a concentration where the mutant fluid phase and crystalline phase coexist. We find that while the mutant conserves the protein fold, changes to the surface exposure of residues in the neighborhood of residue‐36 enhance protein–protein interactions and develop specific protein–protein contacts found in the protein crystal lattice. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01928651
- Volume :
- 44
- Issue :
- 19
- Database :
- Academic Search Index
- Journal :
- Journal of Computational Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 164202626
- Full Text :
- https://doi.org/10.1002/jcc.27116