Variation in optimal hemodynamic atrio‐ventricular delay of biventricular pacing with different endocardial left ventricular lead locations using precision hemodynamics.

Introduction: It is not known whether the optimal atrioventricular (AVopt) delay varies between left ventricular (LV) pacing site during endocardial biventricular pacing (BiVP) and may therefore needs consideration. Methods: We assessed the hemodynamic AVopt in patients with chronic heart failure undergoing endocardial LV lead implantation. AVopt was assessed during atrio‐BiVP with a "roving LV lead." Up to four locations were studied: mid‐lateral wall, mid‐septum (or a close alternative), site of greatest hemodynamic improvement, and LV lead implant site. The AVopt was compared to a fixed AV delay of 180 ms. Results: Seventeen patients were included (12 male, aged 66.5 ± 12.8 years, ejection fraction 26 ± 7%, 16 left bundle branch block or high percentage of right ventricular pacing [RVP], QRS duration 167 ± 27 ms). In most locations (62/63), AVopt increased systolic blood pressure during BiVP compared with RVP (relative improvement 6 mmHg, interquartile range [IQR] 4–9 mmHg). Compared to a fixed AV delay, the hemodynamic improvement at AVopt was higher (1 mmHg, IQR 0.2–2.6 mmHg, p <.001). Within most patients (16/17), we observed a difference in AVopt between pacing sites (median paced AVopt 209 ms, IQR 117–250). Within this range, the hemodynamic impact of these differences was small (median loss 0.6 mmHg, IQR 0.1–2.6 mmHg). Conclusion: Within a patient, different endocardial LV lead locations have slightly different hemodynamic AVopt which are superior to a fixed AV delay. The hemodynamic consequence of applying an optimum from a different lead location is small. [ABSTRACT FROM AUTHOR]