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Design of a pH-sensitive supramolecular fluorescent probe for selective cancer cell imaging.
- Source :
-
Dyes & Pigments . Sep2023, Vol. 217, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- In this study, a pH-sensitive fluorescent probe was created through the host-guest assembly of an amphiphilic hydroxyphenyl benzotriazole derivative (HBT-11) and cucurbit[7]uril (CB7). The fluorescence of HBT-11 is highly dependent on the molar ratio (r) of CB7 to HBT-11. If r < 1, the peak positions remain unchanged while the intensity increases with r. If r > 1, the emission peaks shift to longer wavelengths. The complexation also results in a shift in the p K a of HBT-11. The 1:1 mixture of CB7 and HBT-11 has a p K a close to neutral pH. The supramolecular probe allows for discrimination of malignant A549 and benign HEK 293T cells owing to a pronounced 8-fold light-up effect in malignant A549 cells attributed to the pH-responsive fluorescence. Given that the selective light-up mechanism is based on the pH-sensitive fluorescence of the supramolecular probe, this approach is expected to be applicable to other cancer cells. [Display omitted] • A pH-sensitive supramolecular fluorescence probe was constructed. • The fluorescent intensity of the probe was greatly enhanced as pH < p K a. • The probe was applied to discriminate malignant and benign cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01437208
- Volume :
- 217
- Database :
- Academic Search Index
- Journal :
- Dyes & Pigments
- Publication Type :
- Academic Journal
- Accession number :
- 164257109
- Full Text :
- https://doi.org/10.1016/j.dyepig.2023.111366