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Impact of platelet endothelial aggregation receptor 1 genotypes and DNA methylation on platelet reactivity in patients with recurrent ischemic stroke treated with clopidogrel.
- Source :
-
Archives of Medical Science . 2023, Vol. 19 Issue 2, p518-522. 5p. - Publication Year :
- 2023
-
Abstract
- Introduction: The aim of this study is to investigate the role of genetic variation and DNA methylation of PEAR1 rs12041331 in high on-treatment platelet reactivity (HPR) and recurrent ischemic stroke (RIS). Methods: Genotype, methylation, and mRNA of PEAR1 rs12041331 were detected in patients with cerebral ischemia, for the analysis of the effect of PEAR1 rs12041331 on HPR and RIS. Results: The major G allele of PEAR1 rs12041331 was associated with hypermethylation, which was associated with HPR. This link was not observed for RIS. Conclusions: The PEAR1 rs12041331 genetic polymorphism and DNA methylation may be among the genetic factors affecting HPR. The correlation between PEAR1 and RIS needs to be studied further. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17341922
- Volume :
- 19
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Archives of Medical Science
- Publication Type :
- Academic Journal
- Accession number :
- 164270252
- Full Text :
- https://doi.org/10.5114/aoms/159180