Electrosynthesis of Thiocyanated/Iodinated/Brominated Pyrazol‐5‐amines and Thiocyanated Enamines via C(sp2)−H Functionalization.

An electrochemical method for the C(sp2)−H thiocyanation of pyrazol‐5‐amines and enamines were developed in an undivided cell. A variety of thiocyanated pyrazol‐5‐amine and enamine derivatives were accessed in 36–91% yields, employing thiocyanate salts as electrolyte and thiocyanating reagent. Moreover, this electrochemical protocol can be extended to the synthesis of various iodinated and brominated pyrazol‐5‐amine derivatives in 51–95% yields. This electrochemical protocol does not require a metal or external chemical oxidants and tolerates unprotected amino groups. [ABSTRACT FROM AUTHOR]