Back to Search
Start Over
The Anterior Cingulate Cortex Promotes Long-Term Auditory Cortical Responses through an Indirect Pathway via the Rhinal Cortex in Mice.
- Source :
-
Journal of Neuroscience . 6/7/2023, Vol. 43 Issue 23, p4262-4278. 17p. - Publication Year :
- 2023
-
Abstract
- Sensory cortical areas are robustly modulated by higher-order cortices. Our previous study shows that the anterior cingulate cortex (ACC) can immediately and transiently enhance responses in the mouse auditory cortex (ACx). Here, we further examined whether strong activation of ACC neurons can induce long-term effects in mice of both sexes. To our surprise, only stimulation of cell bodies in the ACC, but not ACC-to-ACx terminal activation, induced long-term enhancement of auditory responses in the ACx. Anatomical examination showed that the ACC indirectly projects to the ACx via the rhinal cortex (RCx). High-frequency stimulation of ACC-projecting terminals to the RCx or RCx-projecting terminals to the ACx induced a similar effect as the cell body activation of ACC neurons, whereas silencing the RCx blocked this long-term enhancement. High-frequency stimulation of ACC projections to the RCx also induced long-term augmentation of sound-evoked flight behavior in male mice. These results show that the ACC promotes the longterm enhancement of auditory responses in the ACx through an indirect pathway via the RCx. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CINGULATE cortex
*AUDITORY cortex
*MICE
*NEURONS
Subjects
Details
- Language :
- English
- ISSN :
- 02706474
- Volume :
- 43
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Journal of Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 164326296
- Full Text :
- https://doi.org/10.1523/JNEUROSCI.2252-22.2023