Inhalation delivery of dexamethasone with iSEND nanoparticles attenuates the COVID-19 cytokine storm in mice and nonhuman primates.

The article discusses the development of an inhaled delivery system, iSEND, using nanovesicles loaded with dexamethasone (DEX) to attenuate the cytokine storm in COVID-19 disease. Inhalation of nanoDEX showed improved anti-inflammatory effects with a lower dose compared to intravenous administration, presenting a safe and effective treatment platform for COVID-19.