SGLT2 breast expression could affect the cardiovascular performance in pre-menopausal women with fatty vs. non fatty breast via over-inflammation and sirtuins' down regulation.

• Pre-menopausal women with lowest breast fat-density (fatty breast) vs. higher breast fat-density (non-fatty breast) are high-risk population for cardiovascular diseases and worse prognosis. • The worse cardiovascular prognosis could be due to expression in the breast fat tissue in fatty vs. non-fatty pre-menopausal women of sodium glucose transporter 2 (SGLT2), inflammatory cytokines and sirtuins. • Indeed, these molecular effectors could condition the intima-media wall thickness (IMT), left ventricle mass (LVM), left ventricle ejection fraction (LVEF), and myocardial performance index (MPI), and its normalization. • The fatty vs. non-fatty breast women over-expressed SGLT2/inflammatory cytokines, and down-regulated breast sirtuins. • SGLT2/inflammatory cytokines expression and inversely the tSIRT3 and breast percentage density linked to ΔMPI at 1 year of follow-up. • Fatty breast and SGLT2 inversely predicted the normalization of cardiac performance (NCP). • SIRT-3 increased the probability of NCP at 1 year of follow-up. To evaluate the expression of sodium-glucose transporter 2 (SGLT2), inflammatory cytokines, and sirtuins in breast fat tissue at baseline, and serum cytokines of fatty vs. non-fatty pre-menopausal women at baseline, and at 12 months of follow-up. To correlate SGLT2/cytokines/sirtuins expression to clinical variables, and their changes (Δ) at follow-up, as intima-media wall thickness (IMT), left ventricle mass (LVM), left ventricle ejection fraction (LVEF), and myocardial performance index (MPI), and its normalization. Pre-menopausal women with the lowest breast fat density (fatty breast) vs. higher breast fat density (non-fatty breast) are a high-risk population for cardiovascular diseases and worse prognosis. We analyzed SGLT2/cytokines/sirtuins of excised fatty breasts of fatty vs. non-fatty pre-menopausal women. We correlated SGLT2/cytokines/sirtuins to Δ IMT, Δ LVM, Δ LVEF, and Δ MPI, and normal cardiac performance (NCP) at 1 year of follow-up. fatty vs. non-fatty breast over-expressed SGLT2/inflammatory cytokines, with lowest values of sirtuins (p <0.05). We found a direct correlation between SGLT2 (R2 0.745), TNFα (R2 0.262), and ΔMPI (p <0.05), and an inverse correlation between breast density (R2 -0.198), SIRT-3 (R2–0.181), and ΔMPI (p <0.05). Fatty breast (0.761, CI 95% [0.101–0.915]), SGLT2 (0.812, CI 95% [0.674–0.978]) and SIRT-3 (1.945, CI 95% [1.201–3.148]) predicted NCP at 1 year of follow-up. fatty vs. non-fatty breast women over-expressed SGLT2/inflammatory cytokines, and down-regulated breast sirtuins. SGLT2/inflammatory cytokines expression and inversely the tissue sirtuin 3 (tSIRT3) and breast percentage density linked to ΔMPI at 1 year of follow-up. Fatty breast and SGLT2 inversely predicted NCP; SIRT-3 increased the probability of NCP at 1 year of follow-up. [Display omitted] [ABSTRACT FROM AUTHOR]