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HM-Chromanone Alleviates Hyperglycemia by Protecting Pancreatic Islet Cells in Streptozotocin-Induced Diabetic Mice.
- Source :
-
Journal of Medicinal Food . Jun2023, Vol. 26 Issue 6, p357-367. 11p. - Publication Year :
- 2023
-
Abstract
- We examined the effects of HM-chromanone (HMC) on alleviating hyperglycemia and protecting pancreatic β-cells from streptozotocin (STZ)-induced damage in C57BL/6J mice. HMC was administered to STZ-induced diabetic mice at 10 or 30 mg/kg, for 14 days. Thereafter, changes in fasting blood glucose levels, insulin-secretion, histopathological examination of pancreas islet cell and apoptotic protein levels, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay were determined. The results revealed that HMC dose-dependently improved blood glucose concentrations and alleviated pancreatic islet cells damage. In diabetic mice, degeneration of the islet cells was observed wherein they appeared shrunken, with hyaline deterioration, nuclear dissolution, and condensation. However, morphology of the islet cell was restored, and nuclei were visibly rounded in the HMC (30 mg/kg)-administered diabetic mice. In addition, β-cell numbers were markedly increased in HMC mice compared to STZ-induced diabetic mice, and the number of cells stained with glucagon was decreased. HMC markedly decreased the expression of proapoptotic proteins and increased antiapoptotic proteins, and the number of apoptotic cells detected by TUNEL was elevated. HMC decreased expression of interleukin (IL)-1β, IL-6, and tumor necrosis factor-α in diabetic mice. Moreover, HMC increased antioxidant-enzymes activity, and decreased reactive oxygen species generation. In conclusion, the results demonstrate the potential of HMC to alleviate hyperglycemia by protecting the pancreatic β-cells in diabetic mice. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HYPERGLYCEMIA prevention
*BIOLOGICAL models
*INTERLEUKINS
*PANCREAS
*BLOOD proteins
*STAINS & staining (Microscopy)
*ANIMAL experimentation
*ISOFLAVONES
*DIABETES
*AMINOGLYCOSIDES
*BLOOD sugar
*ANTIOXIDANTS
*ISLANDS of Langerhans
*HISTOLOGICAL techniques
*TRANSFERASES
*TUMOR necrosis factors
*EXOCRINE glands
*RESEARCH funding
*MOLECULAR structure
*REACTIVE oxygen species
*MICE
*NUCLEIC acids
*PANCREATIC beta cells
Subjects
Details
- Language :
- English
- ISSN :
- 1096620X
- Volume :
- 26
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Medicinal Food
- Publication Type :
- Academic Journal
- Accession number :
- 164347298
- Full Text :
- https://doi.org/10.1089/jmf.2022.K.0084