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Chitosan functionalized Mn3O4 nanoparticles counteracts ulcerative colitis in mice through modulation of cellular redox state.

Authors :
Mondal, Susmita
Das, Monojit
Ghosh, Ria
Singh, Manali
Adhikari, Aniruddha
Darbar, Soumendra
Kumar Das, Anjan
Bhattacharya, Siddhartha Sankar
Pal, Debasish
Bhattacharyya, Debasish
Ahmed, Ahmed S. A.
Mallick, Asim Kumar
Al-Rooqi, Munirah M.
Moussa, Ziad
Ahmed, Saleh A.
Pal, Samir Kumar
Source :
Communications Biology. 6/16/2023, Vol. 6 Issue 1, p1-14. 14p.
Publication Year :
2023

Abstract

Recent findings suggest a key role for reactive oxygen species (ROS) in the pathogenesis and progression of ulcerative colitis (UC). Several studies have also highlighted the efficacy of citrate functionalized Mn3O4 nanoparticles as redox medicine against a number of ROS-mediated disorders. Here we show that synthesized nanoparticles consisting of chitosan functionalized tri-manganese tetroxide (Mn3O4) can restore redox balance in a mouse model of UC induced by dextran sulfate sodium (DSS). Our in-vitro characterization of the developed nanoparticle confirms critical electronic transitions in the nanoparticle to be important for the redox buffering activity in the animal model. A careful administration of the developed nanoparticle not only reduces inflammatory markers in the animals, but also reduces the mortality rate from the induced disease. This study provides a proof of concept for the use of nanomaterial with synergistic anti-inflammatory and redox buffering capacity to prevent and treat ulcerative colitis. Chitosan- Mn3O4 nanoparticles are characterized and shown to counteract redox imbalance and inflammation, and reduce mortality in a mouse model of ulcerative colitis. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
23993642
Volume :
6
Issue :
1
Database :
Academic Search Index
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
164372386
Full Text :
https://doi.org/10.1038/s42003-023-05023-6