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Causative germline variant p.Y259C of DDX41 recurrently identified in acute lymphoblastic leukaemia.
- Source :
-
British Journal of Haematology . Jul2023, Vol. 202 Issue 1, p199-203. 5p. - Publication Year :
- 2023
-
Abstract
- I DDX41 i mutations were detected in 0.6% (2/329) adult ALL patients of our cohorts comparable with a recent report.[10] Previous studies showed that I DDX41 i -mutated patients of MNs presented as male predominance and old age. Germline DDX41 mutations define a significant entity within adult MDS/AML patients. We found three variants in I DDX41 i (p.R525H, p.G530D and p.Y259C) and confirmed the germline origin of p.Y259C of I DDX41 i by Sanger sequencing. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 00071048
- Volume :
- 202
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- British Journal of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 164487467
- Full Text :
- https://doi.org/10.1111/bjh.18848