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Stereoselective Synthesis of Contiguous Cyclopropylaziridines: Enabling the Construction of Versatile Chiral Molecules Including γ‐Lactams via Ring‐Opening Reactions.
- Source :
-
Advanced Synthesis & Catalysis . 6/20/2023, Vol. 365 Issue 12, p1970-1976. 7p. - Publication Year :
- 2023
-
Abstract
- The synthesis of chiral contiguous cyclopropylaziridine was achieved through cyclopropanation of (E)‐3‐((S)‐1‐[(R)‐1‐phenylethyl)aziridin‐2‐yl]acrylaldehyde with bromomalonate in the presence of (2R)‐ or (2S)‐[diphenyl(trimethylsilyloxy) methyl]pyrrolidine as a chiral organocatalyst and 2,6‐lutidine as a base. This chiral cyclopropylaziridine was then subjected to various functional transformations, leading to the construction of a wide range of structurally important motifs. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RING-opening reactions
*CYCLOPROPANATION
*MOLECULES
*LACTAMS
*ACROLEIN
*PYRROLIDINE
Subjects
Details
- Language :
- English
- ISSN :
- 16154150
- Volume :
- 365
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Advanced Synthesis & Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- 164587639
- Full Text :
- https://doi.org/10.1002/adsc.202300177