Stereoselective Synthesis of Contiguous Cyclopropylaziridines: Enabling the Construction of Versatile Chiral Molecules Including γ‐Lactams via Ring‐Opening Reactions.

The synthesis of chiral contiguous cyclopropylaziridine was achieved through cyclopropanation of (E)‐3‐((S)‐1‐[(R)‐1‐phenylethyl)aziridin‐2‐yl]acrylaldehyde with bromomalonate in the presence of (2R)‐ or (2S)‐[diphenyl(trimethylsilyloxy) methyl]pyrrolidine as a chiral organocatalyst and 2,6‐lutidine as a base. This chiral cyclopropylaziridine was then subjected to various functional transformations, leading to the construction of a wide range of structurally important motifs. [ABSTRACT FROM AUTHOR]