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Targeting cGAS/STING signaling-mediated myeloid immune cell dysfunction in TIME.
- Source :
-
Journal of Biomedical Science . 6/28/2023, Vol. 30 Issue 1, p1-21. 21p. - Publication Year :
- 2023
-
Abstract
- Myeloid immune cells (MICs) are potent innate immune cells serving as first responders to invading pathogens and internal changes to cellular homeostasis. Cancer is a stage of altered cellular homeostasis that can originate in response to different pathogens, chemical carcinogens, and internal genetic/epigenetic changes. MICs express several pattern recognition receptors (PRRs) on their membranes, cytosol, and organelles, recognizing systemic, tissue, and organ-specific altered homeostasis. cGAS/STING signaling is a cytosolic PRR system for identifying cytosolic double-stranded DNA (dsDNA) in a sequence-independent but size-dependent manner. The longer the cytosolic dsDNA size, the stronger the cGAS/STING signaling activation with increased type 1 interferon (IFN) and NF-κB-dependent cytokines and chemokines' generation. The present article discusses tumor-supportive changes occurring in the tumor microenvironment (TME) or tumor immune microenvironment (TIME) MICs, specifically emphasizing cGAS/STING signaling-dependent alteration. The article further discusses utilizing MIC-specific cGAS/STING signaling modulation as critical tumor immunotherapy to alter TIME. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10217770
- Volume :
- 30
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Biomedical Science
- Publication Type :
- Academic Journal
- Accession number :
- 164609188
- Full Text :
- https://doi.org/10.1186/s12929-023-00942-2