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Leveraging Plasma Membrane Repair Therapeutics for Treating Neurodegenerative Diseases.

Authors :
Bulgart, Hannah R.
Goncalves, Isabella
Weisleder, Noah
Source :
Cells (2073-4409). Jun2023, Vol. 12 Issue 12, p1660. 15p.
Publication Year :
2023

Abstract

Plasma membrane repair is an essential cellular mechanism that reseals membrane disruptions after a variety of insults, and compromised repair capacity can contribute to the progression of many diseases. Neurodegenerative diseases are marked by membrane damage from many sources, reduced membrane integrity, elevated intracellular calcium concentrations, enhanced reactive oxygen species production, mitochondrial dysfunction, and widespread neuronal death. While the toxic intracellular effects of these changes in cellular physiology have been defined, the specific mechanism of neuronal death in certain neurodegenerative diseases remains unclear. An abundance of recent evidence indicates that neuronal membrane damage and pore formation in the membrane are key contributors to neurodegenerative disease pathogenesis. In this review, we have outlined evidence supporting the hypothesis that membrane damage is a contributor to neurodegenerative diseases and that therapeutically enhancing membrane repair can potentially combat neuronal death. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20734409
Volume :
12
Issue :
12
Database :
Academic Search Index
Journal :
Cells (2073-4409)
Publication Type :
Academic Journal
Accession number :
164611928
Full Text :
https://doi.org/10.3390/cells12121660