Diuretic medication and change in fluid retention biomarkers during treatment with the endothelin receptor antagonist atrasentan.

However, after accounting for differences in patient characteristics between patients using loop and thiazide diuretics, we did not observe a significant difference in fluid retention biomarkers between patients stably using these two classes of diuretic agents. Of those, 1514 patients used a loop diuretic, 1303 used a thiazide diuretic, and 93 used a combination of both a loop and a thiazide diuretic in a stable dose throughout the enrichment phase. Loop and thiazide diuretics are frequently used in patients with CKD, with loop diuretics recommended in patients with more advanced kidney disease. [Extracted from the article]