Real‐Time Monitoring of Dynamic Chemical Processes in Microbial Metabolism with Optical Sensors.

Monitoring microbial metabolism is vital for revealing the mechanism of disease related to microbial metabolism and providing guidance for biomanufacturing processes optimization. However, it remains a grand challenge to offer real‐time insights into microbial metabolism owing to the complex and dynamic process. In this paper, the recent advances and prospects of optical biosensors including the organic, genetic coding and inorganic optical biosensors are briefly described for real‐time monitoring of dynamic microbial metabolism. This paper points out that challenges remain in microbial heterogeneity. We believe that this work will inspire the application of developing new methods for single cell real‐time analysis. [ABSTRACT FROM AUTHOR]