Time Spent in Hypoglycemia According to Age and Time of Day: Observations During Closed-Loop Insulin Delivery.

Objective: We aimed to assess whether percentage of time spent in hypoglycemia during closed-loop insulin delivery differs by age group and time of day. Methods: We retrospectively analyzed data from hybrid closed-loop studies involving young children (2–7 years), children and adolescents (8–18 years), adults (19–59 years), and older adults (≥60 years) with type 1 diabetes. Main outcome was time spent in hypoglycemia <3.9 mmol/L (<70 mg/dL). Eight weeks of data for 88 participants were analyzed. Results: Median time spent in hypoglycemia over the 24-h period was highest in children and adolescents (4.4% [interquartile range 2.4–5.0]) and very young children (4.0% [3.4–5.2]), followed by adults (2.7% [1.7–4.0]), and older adults (1.8% [1.2–2.2]); P < 0.001 for difference between age groups. Time spent in hypoglycemia during nighttime (midnight–05:59) was lower than during daytime (06:00–23:59) across all age groups. Conclusion: Time in hypoglycemia was highest in the pediatric age group during closed-loop insulin delivery. Hypoglycemia burden was lowest overnight across all age groups. [ABSTRACT FROM AUTHOR]