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Research progress on ion channels and their molecular regulatory mechanisms in the human sperm flagellum.

Authors :
Cong, Shengnan
Zhang, Jingjing
Pan, Feng
Pan, Lianjun
Zhang, Aixia
Ma, Jiehua
Source :
FASEB Journal. Jul2023, Vol. 37 Issue 7, p1-11. 11p.
Publication Year :
2023

Abstract

The ion channels in sperm tail play an important role in triggering key physiological reactions, e.g., progressive motility, hyperactivation, required for successful fertilization. Among them, CatSper and KSper have been shown to be important ion channels for the transport of Ca2+ and K+. Moreover, the voltage‐gated proton channel Hv1, the sperm‐specific sodium‐hydrogen exchanger (sNHE), the epithelial sodium channel (ENaC), members of the temperature‐sensitive TRP channel family, and the cystic fibrosis transmembrane regulator (CFTR) are also found in the flagellum. This review focuses on the latest advances in ion channels located at the flagellum, describes how they affect sperm physiological function, and summarizes some primary mutual regulation mechanism between ion channels, including PH, membrane potential, and cAMP. These ion channels may be promising targets for clinical application in infertility. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
08926638
Volume :
37
Issue :
7
Database :
Academic Search Index
Journal :
FASEB Journal
Publication Type :
Academic Journal
Accession number :
164780861
Full Text :
https://doi.org/10.1096/fj.202300756R