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The Efficacy and Safety of Etripamil Nasal Spray for Acute Paroxysmal Supraventricular Tachycardia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- Source :
-
American Journal of Cardiovascular Drugs . Jul2023, Vol. 23 Issue 4, p379-391. 13p. - Publication Year :
- 2023
-
Abstract
- Background: Paroxysmal supraventricular tachycardia (PSVT) treatment requires medically supervised intervention. Etripamil is a novel short-acting calcium channel blocker. Its intranasal spray formulation has a rapid onset of action and shows promise for the unsupervised treatment of PSVT. Objective: We aimed to evaluate the efficacy and safety of etripamil nasal spray for the acute conversion of PSVT. Methods: A systematic review and meta-analysis synthesizing randomized controlled trials (RCTs), which were retrieved by systematically searching the PubMed, EMBASE, Web of Science, SCOPUS, and Cochrane databases through to 1 December 2022. RevMan version 5.4 software was used to pool dichotomous outcomes using risk ratio (RR) presented with the corresponding confidence interval (CI). Results: Three RCTs with a total of 496 participants were included in our analysis. Etripamil was effective for PSVT conversion at 15 min (RR 1.84, 95% CI 1.37–2.48), 30 min (RR 1.86, 95% CI 1.42–2.44), and 60 min (RR 1.25, 95% CI 1.05–1.50) after drug administration; decreasing medical intervention-seeking (RR 0.58, 95% CI 0.37–0.90); and decreasing emergency room (ER) visits (RR 0.61, 95% CI 0.38–0.97). However, there was no difference at 300 min (RR 1.10, 95% CI 0.97–1.25) and it was associated with higher rates of adverse events (RR 3.17, 95% CI 2.15–4.69). Conclusion: Etripamil nasal spray was effective and well tolerated to induce PSVT termination for up to 60 min. Therefore, etripamil nasal spray constitutes a promising strategy for PSVT self-termination without medical supervision; however, further RCTs are required before endorsement in clinical practice. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DRUG efficacy
*ONLINE information services
*MEDICAL databases
*AEROSOLS
*META-analysis
*MEDICAL information storage & retrieval systems
*CONFIDENCE intervals
*HOSPITAL emergency services
*CALCIUM antagonists
*SYSTEMATIC reviews
*SUPRAVENTRICULAR tachycardia
*RESEARCH funding
*MEDLINE
*PATIENT safety
Subjects
Details
- Language :
- English
- ISSN :
- 11753277
- Volume :
- 23
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- American Journal of Cardiovascular Drugs
- Publication Type :
- Academic Journal
- Accession number :
- 164782780
- Full Text :
- https://doi.org/10.1007/s40256-023-00592-7