Enantioselective Synthesis of Axially Chiral 1-Arylisoquinolines by Iridium(I)-Catalyzed Hydroarylation of Alkynes.

Alkynes, isoquinolines, axial chirality, C-H functionalization, iridium catalysis, asymmetric synthesis Then, isoquinoline 1 (0.2 mmol), alkyne 2 (0.2 mmol), and NaBAr F (35.4 mg, 0.04 mmol, 20 mol%) were added under argon and the tube was heated at 80 °C for 10-24 h. Keywords: alkynes; isoquinolines; axial chirality; C-H functionalization; iridium catalysis; asymmetric synthesis EN alkynes isoquinolines axial chirality C-H functionalization iridium catalysis asymmetric synthesis 1442 1446 5 07/11/23 20230725 NES 230725 Graph Transition-metal-catalyzed enantioselective C-H functionalization represents one of the most valuable and straightforward routes to optically active molecules by direct transformations of C-H compounds. [Extracted from the article]