Ligand-Promoted Rosenmund–von Braun Reaction.

Aryl nitriles, cyanation, coupling reaction, ligand, copper cyanide Remarkably, these reactions often proceed at relatively low temperatures and catalytic loadings in comparison with previous ligand-promoted Cu-catalyzed coupling reactions with (hetero)aryl halides. Keywords: aryl nitriles; cyanation; coupling reaction; ligand; copper cyanide EN aryl nitriles cyanation coupling reaction ligand copper cyanide 1395 1398 4 07/11/23 20230725 NES 230725 Graph Aryl nitriles have been frequently found in various drug molecules, dyes, and natural products. This result indicated that the active copper center coordinated with ligand might hinder I ortho i -substituted aryl bromide's approaching, showing a significant difference in reaction mechanism from the traditional Rosenmund-von Braun reaction. [Extracted from the article]