Synthesis of 5-substituted-1H-tetrazoles using zinc zirconium phosphate and copper zirconium phosphate as reusable heterogeneous catalysts.

Zinc zirconium phosphate and copper zirconium phosphate were used as reusable and efficient heterogeneous catalysts for the synthesis of 5-substituted-1H-tetrazoles through the [3 + 2] cycloaddition between various nitriles and sodium azide in N,N- dimethylformamide as solvent at 120 °C. This synthetic pathway has significant benefits, such as simple methodology, easy work-up procedure, and high yields. In addition, these nanocatalysts have no toxic metals and can be efficiently recycled up to several consecutive runs. [ABSTRACT FROM AUTHOR]