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Chemical Modification of Peptides and Proteins Using Spirooxindole Oxirane Derivatives.
- Source :
-
Advanced Synthesis & Catalysis . 7/4/2023, Vol. 365 Issue 13, p2171-2176. 6p. - Publication Year :
- 2023
-
Abstract
- Methods for chemical modification of proteins and peptides at certain positions are required for the preparation of antibody‐drug conjugates, protein‐ or peptide‐biotin conjugates, and conjugates used as therapeutics or as tools in biomedical research. We have developed chemical modification methods that use spirooxindole oxirane derivatives for the synthesis of protein‐ and peptide‐conjugates. In most cases, the epoxide group of the spirooxindole oxirane derivatives reacted to form a covalent bond with certain histidine residues and/or the N‐terminal amino group of peptides and proteins. The modification reactions of various proteins resulted in the formation of proteins modified at only one or two positions. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16154150
- Volume :
- 365
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Advanced Synthesis & Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- 164876493
- Full Text :
- https://doi.org/10.1002/adsc.202300578