Hipoksik İskemik Ensefalopatide Umblikal Kord Ph ve İzlemde Alınan Kardiyak Belirteçlerin Yenidoğan ve Bebeklik Dönemi Nörogelişimsel Sonuçlara Etkisi.

Aim: Hypoxic ischemic encephalopathy (HIE); It is a clinical condition that can progress with abnormal consciousness, seizures, and multi-organ failure. In this retrospective study, it was aimed to evaluate the cord blood gas pH value and cardiac markers, as well as diffusion magnetic resonance imaging (MRI), neurological examinations and developmental results of newborns diagnosed with HIE who underwent therapeutic hypothermia (TH). Materials-Methods: Patients who were hospitalized in the Neonatal Intensive Care Unit of Hacettepe University İhsan Doğramacı Children's Hospital between January 2015 and January 2021 and received TH treatment with the diagnosis of HIE stage 2-3 and were followed up in the outpatient clinic were included in the study. Umbilical cord blood gas pH, Troponin-I, CK-MB values, diffusion MRI findings and Bayley Developmental Assessment Scale for Infants and Young Children-lll (BSID-III) results werecompared. Results: Mean gestational week of 17 patients included in the study was 39 weeks (37-41), mean birth weight was 3360 ± 325 g, 13 (59%) were male. Seizures were not detected in 10 (59%) of the patients in aEEG/EEG follow-up. There was no statistical difference between the median cord blood gas pH value and abnormal diffusion MRI results. Between the BSID-III scoresand the median ofthe cord blood gas pH; There was no statistical difference between heart markers and diffusion MRI and BSID-III results. Conclusion: Cord blood gas values used for TH indication in infants with hypoxic ischemic encephalopathy are not sufficient to predict long-term neurodevelopmental prognosis. If the number of patients is increased, we can say that cardiac enzymes, which show that the heart muscle is affected by hypoxia in these patients, may be useful in predicting the neurological-developmental problems that the baby may presence in long-term follow-up. [ABSTRACT FROM AUTHOR]