Genes affecting in cytokine storm as therapeutic targets in COVID-19 infection.

Background: A cytokine storm is an abnormal host immune system response and a principal responsibility for the incidence of acute respiratory distress syndrome. The existence of the virus-induced cytokine has been linked to mortality in patients with COVID-19. This study aimed to review the gene's role in cytokine storm as a therapeutic target in patients with COVID-19. We demonstrated the role of pro-inflammatory cytokines in conditions that are often associated with COVID-19. Hyperproduction of mostly pro-inflammatory cytokines such as IFN-γ, IL-6, IL-1, TNF-α, and Chemokines, which target lung tissue preferentially, can significantly worsen the prognosis in almost all cases. The cytokines' data in this disease will support the development of more useful COVID-19 patient management strategies. In managing COVID-19 patients, targeting cytokines can decrease mortality and increase survival rates. [ABSTRACT FROM AUTHOR]