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Platinum/Copper Dual‐Catalyzed Asymmetric Vinylogous Addition Reactions for the Synthesis of Functionalized Indoles.
- Source :
-
Angewandte Chemie International Edition . 7/24/2023, Vol. 62 Issue 30, p1-8. 8p. - Publication Year :
- 2023
-
Abstract
- The development of multicomponent ligands to improve catalytic reactivity and selectivity remains a significant challenge for the synthesis of chiral building blocks. Here, a modular synthesis of structurally diverse multiligated platinum complexes, characterized by X‐ray crystallography, was revealed to open up a previously inaccessible reaction space. A library of more than 16 binary component‐ligated platinum complexes was identified as a practical toolkit to enable faster screening. The isolated bench‐stable PtII(oxazoline)(phosphine) complex paired with a chiral copper complex exhibits fundamentally new cooperative reactivity. The newly designed Pt/Cu dual catalytic system contributed to the development of highly enantioselective vinylogous addition reactions between a Pt‐activated electrophilic α,β‐unsaturated carbene and a Cu‐activated nucleophile, resulting in a reliable process for the asymmetric synthesis of valuable functionalized indoles in good yields and excellent enantioselectivities. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 62
- Issue :
- 30
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 165045544
- Full Text :
- https://doi.org/10.1002/anie.202305638