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Adropin is Involved in the Ameliorative Effect of Chronic Exercise in Nonalcoholic Fatty Liver Rat Model.
- Source :
-
Zagazig University Medical Journal . Jul/Aug2023, Vol. 29 Issue 4, p1071-1085. 15p. - Publication Year :
- 2023
-
Abstract
- Background: Non-alcoholic fatty liver disease (NAFLD) is characterized by abnormal fat metabolism in the liver due to nonalcoholic causes. Adropin is a peptide hormone with an essential role in maintaining metabolic homeostasis. Methods: 42 male rats were divided into 2 groups, each group was subdivided into 3 subgroups: group Ia: control 4 weeks; group Ib: high fat diet (HFD) 4 weeks, group Ic: HFD 4 weeks +exercise; group IIa: control 12 weeks, group IIb: HFD 12 weeks; and group IIc: HFD 12 weeks + exercise. Serum Adropin, glucose, HOMA-IR, insulin, lipid profile, ALT, AST, TNFα, IL6, hepatic ROS, MDA, and SOD were measured. Histopathological examination, immunohistochemical study, and Mallory's trichrome staining of the liver were performed. Results: significant increases in insulin resistance, lipid profile parameters, ALT, AST, TNFα, IL6, hepatic ROS, MDA, and a decrease in SOD were found in HFD groups. Histopathological examination revealed steatosis in group Ib and steatohepatitis in group IIb. These changes were associated with a decrease in serum adropin levels. Exercise in groups Ic and IIc improved these changes with a significant increase in adropin level. Conclusion: HFD induced functional and structural deterioration in the liver, leading to NAFLD with a significant decrease in serum adropin level. Exercise induced a significant increase in serum adropin, which may have a role in the remission of hepatic inflammation, steatosis, and steatohepatitis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11101431
- Volume :
- 29
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Zagazig University Medical Journal
- Publication Type :
- Academic Journal
- Accession number :
- 165099232
- Full Text :
- https://doi.org/10.21608/zumj.2023.197729.2760