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Interleukin-6 in retinal diseases: From pathogenesis to therapy.
- Source :
-
Experimental Eye Research . Aug2023, Vol. 233, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- Interleukin-6 (IL-6) is a pleiotropic cytokine that participates in immunomodulation, inflammation, increases vascular permeability, hematopoiesis, and stimulates cell proliferation, among other biological processes. It exerts effects primarily through the classic and trans-signaling pathways. Many studies have demonstrated that IL-6 plays a critical role in the development of retinal diseases including diabetic retinopathy, uveitis, age-related macular degeneration, glaucoma, retinal vein occlusion, central serous chorioretinopathy and proliferative vitreoretinopathy. Thus, the progressive development of drugs targeting IL-6 and IL-6 receptor may play a role in the treatment of multiple retinal diseases. In this article, we comprehensively review the IL-6's biological functions of and its mechanisms in the pathogenesis of various retinal diseases. Furthermore, we summarize the drugs targeting IL-6 and its receptor and prospect their potential application in retinal diseases, hoping to provide new ideas for the treatment of retinal diseases. • Interleukin-6 (IL-6) participates in immunomodulation and inflammation response process. • IL-6 plays a critical role in the pathogenesis of various retinal diseases. • Targeting IL-6 and IL-6R is a potential therapeutic approach for retinal diseases. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00144835
- Volume :
- 233
- Database :
- Academic Search Index
- Journal :
- Experimental Eye Research
- Publication Type :
- Academic Journal
- Accession number :
- 165114351
- Full Text :
- https://doi.org/10.1016/j.exer.2023.109556