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Gastrointestinal digestion and absorption of soybean β-conglycinin in an early weaned piglet model: An initial step to the induction of soybean allergy.
- Source :
-
Food Chemistry . Nov2023, Vol. 427, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- • β-Conglycinin was resistant to gastrointestinal digestion in early weaned piglets. • The resultant digestion-resistant fragments were absorbed into the intestinal mucosa. • These fragments were observed to be absorbed through transcellular pathway. • The absorption occurred in the form of IgE-allergen complex with CD23 as the receptor. To date, it still remains unknown how β-conglycinin, a major soybean allergen, crosses intestinal epithelial barrier to reach immune cells. The purpose of this study was to elucidate the pathway and molecular mechanism of β-conglycinin absorption and transport across intestinal mucosal epithelium using a β-conglycinin allergic piglet model. Ten-day old piglets were orally sensitized with diets containing 2% and 4% β-conglycinin. The digestion, absorption and transport of β-conglycinin in gastrointestinal tract was investigated. The results showed that β-conglycinin had a certain resistance to gastrointestinal digestion, and the digestion-resistant subunits and fragments were absorbed into the intestinal mucosa and then induced an anaphylaxis in early weaned piglets. The absorption occurred in the form of IgE-allergen immune complex through transcellular pathway with CD23 as the receptor. These results provided important clues for using the pathway and molecule as inhibitor target to prevent and alleviate soybean β-conglycinin allergy in infants. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PIGLETS
*TRANSCYTOSIS
*SOYBEAN
*DIGESTION
*ABSORPTION
*IMMUNOGLOBULIN E
*INTESTINES
Subjects
Details
- Language :
- English
- ISSN :
- 03088146
- Volume :
- 427
- Database :
- Academic Search Index
- Journal :
- Food Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 165122851
- Full Text :
- https://doi.org/10.1016/j.foodchem.2023.136640