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Gold‐Catalyzed Amine Cascade Addition to Diyne‐Ene: Enantioselective Synthesis of 1,2‐Dihydropyridines.
- Source :
-
Angewandte Chemie International Edition . Aug2023, Vol. 62 Issue 31, p1-6. 6p. - Publication Year :
- 2023
-
Abstract
- With the well‐documented chemical and biological applications, piperidine and pyridine are among the most important N‐heterocycles, and a new synthetic strategy, especially one with an alternative bond‐forming design, is of general interest. Using the gold‐catalyzed intermolecular condensation of amine and diyne‐ene, we report herein the first example of enantioselective 1,2‐dihydropyridine synthesis through a formal [3+2+1] fashion (up to 95 % yield, up to 99 % e.e.). [ABSTRACT FROM AUTHOR]
- Subjects :
- *AMINES
*PIPERIDINE
*PYRIDINE
*CONDENSATION
*DIHYDROPYRIDINE
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 62
- Issue :
- 31
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 166735155
- Full Text :
- https://doi.org/10.1002/anie.202305409