166 例门诊癫痫患儿抗癫痫药超说明书使用情况及影响因素分析.

OBJECTIVE: To investigate the off-label use of antiepileptic drugs in outpatient children with epilepsy, and to explore its influencing factors, so as to provide reference for rational use of antiepileptic drugs in children. METHODS: The cases of children with epilepsy in pediatric outpatient department of Chinese PLA General Hospital from Jan.2019 to Nov.2020 were summarized, and whether there was off-label drug use in the prescription of antiepileptic drugs was judged according to the contents of drug instructions.The types of off-label drug use and the offlabel use of various antiepileptic drugs were analyzed statistically, and the influencing factors of off-label drug use were discussed by univariate analysis. RESULTS: A total of 193 children with epilepsy were enrolled, of which 166 children were treated with antiepileptic drugs, totally 249 case-times of antiepileptic drugs.The three main types of off-label drug use were off-label age administration (85 case-times, 34. 1%), over single drug/additive administration (49 casetimes, 19. 7%), and off-label attack types (41 case-times, 16. 5%). Among various antiepileptic drugs, Topiramate tablets (78. 4%, 40/51) and Leveethracetam tablets (58. 8%, 30/51) accounted for a higher proportion of drugs with off-label age administration. Levetiracetam tablets (9. 8%, 5/51) accounted for the highest proportion of over-dose administration, and Clonazepam tablets (13. 6%, 3/22) accounted for the highest proportion of over-frequency administration.Levetiracetam tablets (51. 0%, 26/51) took the lead of off-label attack types, and Levetiracetam tablets (62. 7%, 32/51) accounted for the highest proportion of over single drug/additive administration. CONCLUSIONS: Off-label use of antiepileptic drugs is common in pediatric outpatient department, especially off-label age administration, among which Levetiracetam tablets and Topiramate are the most prominent. Age and basic drugs affect the use of pediatric antiepileptic drugs in our hospital. [ABSTRACT FROM AUTHOR]