加味橘皮竹茹汤联合隔姜灸对中晚期食管癌化疗后肠内营养状态、应激反应及血清 TK-1、Bcl-2 和 miR-451 的影响.

OBJECTIVE: To observe the effects of modified Jupi Zhuru decoction combined with ginger-isolated moxibustion on enteral nutritional status, stress response and serum micrornA-451 (miR-451), thymidine kinase-1 (TK-1) and B-cell lymphoma (Bcl-2) after chemotherapy for advanced esophageal cancer. METHODS: Totally 100 patients with advanced esophageal cancer admitted into Jan. 2020 to Jun. 2021 were extracted. According to the random number table, 50 patients in the control group were given TP chemotherapy regimen (paclitaxel injection + oxaliplatin injection) and enteral treatment, and 50 patients in the study group were given modified Jupi Zhuru decoction combined with ginger-isolated moxibustion on the basis of the control group. T lymphocyte subsets CD4+, CD8+, transferrin, prealbumin, tumor associated cytokeratin 19 fragment (CYFRA21-1), squamous cell carcinoma antigen (SCC-Ag), C-reactive protein (CRP), nitric oxide (NO), cortisol (Cor), superoxide dismutase (SOD), esophageal cancer associated gene 4 (ECRG4), cyclin levels of D1 (CCND1), phosphatase and tensin homolog deleted on chromosome 10 (PTEN), TK-1, Bcl-2 and miR-451 before and after treatment were detected in two groups. The clinical efficacy and adverse reactions were compared between two groups. RESULTS: After treatment, the levels of CD4+, transferrin and prealbumin in the study group were higher than those in the control group, the levels of CD8+ were lower than those in the control group, the levels of Cor and CRP were lower than those in the control group, the levels of SOD and NO were higher than those in the control group, the levels of CCND1 were lower than those in the control group, the levels of ECRG4 and PTEN were higher than those in the control group, the levels of Bcl-2, miR-451 and TK-1 were lower than those of the control group, and the levels of CYFRA21-1 and SCC-Ag were lower than those in the control group, the differences were statistically significant (P<0. 05). The disease control rate of the study group was 96. 00% (48/50), higher than 86. 00% (43/50) of the control group, the difference was statistically significant (P < 0. 05). The incidence of nausea, vomiting, epigastric distension and depression, bone marrow suppression and alopecia in the study group was lower than that in the control group, the differences were statistically significant (P < 0. 05). CONCLUSIONS: Modified Jupi Zhuru decoction combined with ginger-isolated moxibustion in the treatment of patients with advanced esophageal cancer can improve the immune and nutritional status of patients, reduce physiological stress response, decrease the levels of Bcl-2, miR-451 and TK-1, improve the level of tumor suppressor genes, reduce the level of proto-oncogenes and tumor markers, improve clinical efficacy and decrease adverse reactions. [ABSTRACT FROM AUTHOR]