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Interaction of Modified Cyclodextrins with Cytochrome P-450.
- Source :
-
Bioscience, Biotechnology & Biochemistry . Jan2005, Vol. 69 Issue 1, p246-248. 3p. 1 Chart, 1 Graph. - Publication Year :
- 2005
-
Abstract
- Cites a study examining the effects of modified cyclodextrins (CD) hydroxypropyl-β-CD and methyl-β-CD on cDNA-expressed human cytochrome P-450 (CYP) activities. Ability of modified CD to inhibit the activities of CYP2C19 and CYP3A4; Enhancement by CD of the CYP2C9 activity by 140 to 176 percent; Inhibition by methyl-β-CD of CYP1A2 and CYP2D6 at higher concentrations.
Details
- Language :
- English
- ISSN :
- 09168451
- Volume :
- 69
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Bioscience, Biotechnology & Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 16702966
- Full Text :
- https://doi.org/10.1271/bbb.69.246